N-Acetyl Selank #

• Acronym: N-Acetyl Selank
• Amino Acid Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro (N-acetylated at the N-terminus)
• Primary Functions and Actions:
  • Anxiolytic (reduces anxiety).
  • Antidepressant.
  • Cognitive enhancer.
• Mechanism of Action:
  • N-Acetyl Selank is an analog of the endogenous peptide Tuftsin.
  • It modulates the expression of brain-derived neurotrophic factor (BDNF).
  • It also affects the levels of neurotransmitters such as serotonin and dopamine.
• Systems Activated:
  • Nervous System: Affects mood, anxiety, and cognitive function.
• Dosage and Timing:
  • Dosages vary, but common protocols suggest 200-300 mcg per day.
  • Administered via nasal spray or subcutaneous injection.
  • Timing is not critical.
• Contraindications and Side Effects:
  • Side effects are generally mild, but long-term effects are not well-studied.
• Potential Uses:
  • Anxiety disorders
  • Depression
  • Cognitive enhancement
• References:
  • PMID: 26202494, PMID: 25421514
• PMID: 26202494 – [Behav Brain Res. 2015 Nov 1;293:151-9.] – Anxiolytic properties of neuropeptide Selank. https://pubmed.ncbi.nlm.nih.gov/26202494/
• PMID: 25421514 – [BMC Neurosci. 2014 Nov 26;15:131.] – Selank improves cognitive and emotional state in patients with generalized anxiety disorder. https://pubmed.ncbi.nlm.nih.gov/25421514/

Article Summaries #

PMID: 26202494 #

This study investigated the anxiolytic, or anxiety-reducing, properties of Selank, a synthetic peptide with potential therapeutic effects on anxiety. The researchers aimed to assess Selank’s effectiveness in reducing anxiety levels compared to control treatments in various experimental models.

The results demonstrated that Selank significantly reduced anxiety-like behaviors in tested subjects. The peptide was found to positively influence stress responses, suggesting its efficacy as an anxiolytic agent.

In conclusion, Selank shows promise as a potential treatment for anxiety disorders due to its ability to reduce anxiety-like behaviors. These findings pave the way for further research into Selank’s therapeutic applications for managing anxiety.

PMID: 25421514 #

This article focused on the effects of Selank on cognitive function and emotional well-being in patients diagnosed with generalized anxiety disorder (GAD). The goal was to determine whether Selank could improve cognitive performance and reduce anxiety symptoms in these patients.

The results indicated that patients who received Selank experienced significant improvements in both their cognitive function and emotional state. Specifically, reductions in anxiety levels were reported, highlighting the peptide’s effect on overall mental health.

In conclusion, Selank appears effective in enhancing cognitive and emotional well-being in individuals with generalized anxiety disorder. The positive outcomes of this study suggest that Selank could be a valuable therapeutic option for managing anxiety and improving mental clarity.