Kisspeptin #

• Primary Functions and Actions:
  • Stimulates the release of gonadotropin-releasing hormone (GnRH).
  • Regulates reproductive function.
• Mechanism of Action:
  • Kisspeptin is a peptide hormone that binds to the kisspeptin receptor (KISS1R) in the hypothalamus.
  • This binding stimulates the release of GnRH, which in turn stimulates the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland.
  • LH and FSH regulate reproductive function in both males and females.
• Systems Activated:
  • Endocrine System: Primarily affects the reproductive hormone axis.
• Dosage and Timing:
  • Dosages vary, but common protocols suggest 10-20 mcg per kg of body weight.
  • Administered via subcutaneous injection.
  • Timing is not critical.
• Contraindications and Side Effects:
  • Side effects are generally mild, but long-term effects are not well-studied.
  • Potential side effects include nausea, headache, and flushing.
• Potential Uses:
  • Treating infertility
  • Regulating reproductive function
• References:
  • PMID: 16407064, PMID: 17142235
• PMID: 16407064 – [Endocrinology. 2006 Mar;147(3):1170-9.] – Kisspeptin-10 stimulates gonadotropin secretion via GPR54. https://pubmed.ncbi.nlm.nih.gov/16407064/
• PMID: 17142235 – [J Clin Endocrinol Metab. 2007 Feb;92(2):676-80.] – Kisspeptin-54 stimulates gonadotropin release most potently during the preovulatory phase of the menstrual cycle in women. https://pubmed.ncbi.nlm.nih.gov/17142235/

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Article Summaries #

PMID: 16407064 #

This study investigated the role of Kisspeptin-10 in stimulating gonadotropin secretion through its action on the GPR54 receptor. Researchers aimed to understand how this protein affects the release of hormones critical for reproductive functions.

The results showed that Kisspeptin-10 effectively stimulated the secretion of gonadotropins, which include luteinizing hormone (LH) and follicle-stimulating hormone (FSH). This indicates that Kisspeptin-10 plays an important role in the regulatory pathway of reproductive hormones.

In conclusion, the findings suggest that Kisspeptin-10 is a key player in the regulation of gonadotropin secretion via the GPR54 receptor, highlighting its potential importance in reproductive health and therapies for fertility issues.

PMID: 17142235 #

This article explored the effects of Kisspeptin-54 on gonadotropin release, particularly focusing on its potency during the preovulatory phase of the menstrual cycle in women. The goal was to evaluate how this peptide influences hormone levels at this critical time.

The findings revealed that Kisspeptin-54 significantly stimulated the release of gonadotropins, with the most considerable effect observed during the preovulatory phase. This suggests that Kisspeptin-54 plays a crucial role in the hormonal changes necessary for ovulation.

In conclusion, Kisspeptin-54 is a potent stimulator of gonadotropin release, especially during the menstrual cycle’s preovulatory phase. These insights enhance the understanding of reproductive hormone regulation and suggest potential applications in treating fertility-related issues.