Glucagon-Like Peptide-2 (GLP-2) #

• Acronym: GLP-2
• Amino Acid Sequence: His-Ala-Asp-Gly-Ser-Phe-Ser-Asp-Glu-Met-Asn-Thr-Ile-Leu-Asp-Asn-Leu-Ala-Ala-Arg-Asp-Phe-Ile-Asn-Trp-Leu-Ile-Gln-Thr-Lys-Ile-Thr-Asp
• Primary Functions and Actions:
  • Promotes intestinal growth and repair.
  • Enhances nutrient absorption.
  • Reduces intestinal permeability.
• Mechanism of Action:
  • GLP-2 is an incretin hormone secreted from intestinal L-cells.
  • It binds to the GLP-2 receptor (GLP-2R) on intestinal cells, promoting their growth and proliferation.
  • It enhances nutrient absorption by increasing the surface area of the small intestine.
  • GLP-2 reduces intestinal permeability by strengthening the tight junctions between intestinal cells.
• Systems Activated:
  • Digestive System: Primarily affects intestinal growth, repair, and nutrient absorption.
• Dosage and Timing:
  • Teduglutide is a GLP-2 analog used therapeutically.
  • The standard dosage of teduglutide is 0.05 mg/kg body weight, once daily.
  • Administered via subcutaneous injection.
  • Timing is not critical.
• Contraindications and Side Effects:
  • Common side effects include abdominal pain, nausea, vomiting, and fluid retention.
  • Rare but serious side effects include intestinal obstruction and gallbladder disease.
  • Contraindicated in individuals with active gastrointestinal cancer.
• Potential Uses:
  • Short bowel syndrome (SBS)
  • Improving intestinal function after surgery
• References:
  • PMID: 11038304, PMID: 12482963, PMID: 21037244
• PMID: 11038304 – [Am J Physiol Gastrointest Liver Physiol. 2000 Nov;279(5):G981-9.] – Glucagon-like peptide-2: a trophic factor for the intestine. https://pubmed.ncbi.nlm.nih.gov/11038304/
• PMID: 12482963 – [Gastroenterology. 2003 Jan;124(1):22-31.] – Glucagon-like peptide-2. [https://pubmed.ncbi

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Article Summaries: #

PMID: 11038304 #

This article explores glucagon-like peptide-2 (GLP-2) and its role as a trophic factor for the intestine. Researchers aimed to understand how GLP-2 influences intestinal growth and function, particularly its protective effects on the intestinal lining.

The findings indicated that GLP-2 significantly promotes intestinal growth, enhances nutrient absorption, and improves overall gut health in experimental models. The peptide was shown to stimulate the proliferation of intestinal cells and protect against damage from various physiological stressors.

In conclusion, GLP-2 emerges as a critical factor in maintaining intestinal health and function. Its beneficial effects on intestinal tissue suggest potential therapeutic applications for conditions involving gut health and recovery.

PMID: 12482963 #

This study provided a comprehensive overview of glucagon-like peptide-2 (GLP-2), focusing on its biological actions and clinical implications. It aimed to consolidate information regarding GLP-2’s role in gut physiology and potential therapeutic uses, particularly in gastrointestinal disorders.

The review highlighted that GLP-2 promotes intestinal growth, improves nutrient absorption, and has protective properties against stress-induced damage in the intestine. Furthermore, the article discussed the potential of GLP-2 therapy in addressing various gastrointestinal diseases, such as short bowel syndrome.

In conclusion, GLP-2 presents significant therapeutic potential due to its multiple beneficial effects on intestinal health. Its role in promoting gut recovery and functionality emphasizes the need for further research into GLP-2-based treatments for gastrointestinal issues.

PMID: 21037244 #

This article examined the physiological role of glucagon-like peptide-2 (GLP-2) and its implications for gastrointestinal health and disease. The researchers investigated how GLP-2 affects gut hormone interactions and its potential utility in treating gastrointestinal disorders.

The results highlighted that GLP-2 acts by enhancing gut barrier function, promoting cell growth, and influencing the secretion of other gut hormones. The findings suggest that GLP-2 could play a substantial role in the body’s ability to heal and recover from gastrointestinal stress.

In conclusion, GLP-2 serves as an essential player in maintaining gut health and regulating physiological processes. The insights gained from this study emphasize GLP-2’s potential applications in developing novel treatments for gastrointestinal conditions and enhancing overall intestinal well-being.