GHRP-2 #

• Acronym: GHRP-2 (Growth Hormone Releasing Peptide-2)
• Amino Acid Sequence: D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH2
• Primary Functions and Actions:
  • Stimulates the release of growth hormone (GH).
  • Increases appetite.
• Mechanism of Action:
  • GHRP-2 binds to the ghrelin receptor (also known as the growth hormone secretagogue receptor) in the pituitary gland and hypothalamus.
  • This binding stimulates GH release.
  • It also increases ghrelin levels, which can increase appetite.
• Systems Activated:
  • Endocrine System: Primarily affects the growth hormone axis.
• Dosage and Timing:
  • Common dosages range from 100-300 mcg, one to three times per day.
  • Administered via subcutaneous injection.
  • Often taken before meals or before bedtime.
• Contraindications and Side Effects:
  • Potential side effects include increased appetite, increased cortisol levels, and potential for water retention.
  • Contraindicated in individuals with active cancer or a history of cancer.
• Potential Uses:
  • Increasing muscle mass
  • Reducing body fat
• References:
  • PMID: 8897378, PMID: 15249167
• PMID: 8897378 – [J Clin Endocrinol Metab. 1996 Dec;81(12):4245-9.] – Effects of synthetic GHRP-2, a novel growth hormone releasing peptide, on GH secretion in normal subjects. https://pubmed.ncbi.nlm.nih.gov/8897378/
• PMID: 15249167 – [Ann N Y Acad Sci. 2004 Dec;1033:234-44.] – Growth hormone-releasing peptides. https://pubmed.ncbi.nlm.nih.gov/15249167/

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Article Summaries #

PMID: 8897378 #

This study focused on the effects of a synthetic growth hormone-releasing peptide called GHRP-2 on growth hormone (GH) secretion in healthy individuals. The research aimed to evaluate how GHRP-2 could stimulate the release of GH and its potential applications in medical settings.

The results demonstrated that administration of GHRP-2 led to a significant increase in GH secretion among normal subjects. This indicates that GHRP-2 effectively stimulates the pituitary gland to release more growth hormone, which could have implications for treating GH deficiencies or associated conditions.

In conclusion, GHRP-2 shows promise as a potent agent for enhancing GH secretion, offering potential therapeutic applications for individuals with growth hormone-related issues. Its effectiveness in normal subjects supports further exploration of its use in clinical settings.

PMID: 15249167 #

This article provided a comprehensive overview of growth hormone-releasing peptides (GHRPs), discussing their biological properties and clinical applications. The aim was to summarize the various GHRPs available and their mechanisms of action in stimulating GH release.

The review highlighted that GHRPs, including GHRP-2 and others, effectively stimulate GH secretion by acting on specific receptors in the pituitary gland and hypothalamus. Additionally, the article discussed the potential benefits of GHRPs for various conditions, such as GH deficiency and muscle wasting.

In conclusion, GHRPs represent a valuable class of compounds with significant potential for therapeutic applications in enhancing growth hormone secretion. Their multiple beneficial effects make them important candidates for future research and clinical use in managing growth hormone-related disorders.