Epitalon #

• Acronym: Epitalon
• Amino Acid Sequence: Ala-Glu-Asp-Gly (Alanine-Glutamic Acid-Aspartic Acid-Glycine)
• Primary Functions and Actions:
  • Stimulates telomerase activity.
  • Regulates the aging process.
  • May have antioxidant effects.
• Mechanism of Action:
  • Epitalon increases the production of telomerase, an enzyme that lengthens telomeres.
  • Telomeres shorten with age, and lengthening them may promote cellular longevity.
  • It may also regulate gene expression and have antioxidant properties.
• Systems Activated:
  • Endocrine System: Affects the pineal gland and melatonin production.
  • Cellular Level: Impacts telomere length and cellular aging.
• Dosage and Timing:
  • Dosages vary, but a common protocol is 5-10 mg per day for 10-20 days.
  • Administered via subcutaneous injection or nasal spray.
  • Timing is not critical.
• Contraindications and Side Effects:
  • Contraindications are not well-established.
  • Side effects are generally mild, but long-term effects are not well-studied.
• Potential Uses:
  • Anti-aging interventions
  • Age-related diseases
• References:
  • PMID: 14692738, PMID: 12812863
• PMID: 14692738 – [Bull Exp Biol Med. 2003 Dec;136(6):543-6.] – Effect of synthetic tetrapeptide epitalon on the lifespan of Drosophila melanogaster. https://pubmed.ncbi.nlm.nih.gov/14692738/
• PMID: 12812863 – [Adv Gerontol. 2002;10:105-11.] – Effect of epitalon on the characteristics of age-related changes in the neuroendocrine and immune systems. https://pubmed.ncbi.nlm.nih.gov/12812863/

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Article Summaries: #

PMID: 14692738 #

This study investigated the effects of a synthetic tetrapeptide called epitalon on the lifespan of fruit flies (Drosophila melanogaster). Researchers aimed to determine whether epitalon could influence aging and longevity in these organisms.

The results showed that treatment with epitalon significantly extended the lifespan of the fruit flies compared to untreated controls. It was observed that the peptide promoted better health and vitality in the flies as they aged.

In conclusion, the findings suggest that epitalon has potential anti-aging properties, at least in Drosophila melanogaster, and may contribute to increased lifespan and improved health in aging organisms. This opens the door for further exploration of epitalon’s effects on aging in more complex organisms.

PMID: 12812863 #

This article examined the effects of epitalon on age-related changes in the neuroendocrine and immune systems. The research sought to understand how epitalon could influence these systems as they typically undergo decline with aging.

The results indicated that epitalon positively impacted various markers of neuroendocrine and immune function, helping to mitigate age-related declines. Improvements were observed in hormonal levels and immune responses among the subjects treated with epitalon.

In conclusion, the study suggests that epitalon may serve as a beneficial agent in counteracting some of the negative effects associated with aging in the neuroendocrine and immune systems. This highlights its potential role in promoting healthier aging and improving overall well-being in older individuals.