Delta sleep-inducing peptide (DSIP) #

• Primary Functions and Actions:
  • Promotes and restores natural sleep patterns.
  • May have stress-reducing and antioxidant properties.
  • Possible role in regulating hormone release and immune function.
• Mechanism of Action:
  • The exact mechanism of action is still being researched and is not fully understood.
  • DSIP is thought to interact with the hypothalamus and other brain regions involved in sleep regulation.
  • It may modulate the release of neurotransmitters such as GABA, serotonin, and norepinephrine.
  • Some studies suggest it may influence the activity of the delta EEG waves associated with deep sleep.
• Systems Activated:
  • Central Nervous System: Primarily affects sleep-wake regulation.
  • Endocrine System: Possible influence on hormone release.
  • Immune System: Potential immuno-modulatory effects.
• Dosage and Timing:
  • Dosages vary widely in research and anecdotal use.
  • Commonly reported dosages range from 50 mcg to 200 mcg per day.
  • Typically administered 30-60 minutes before bedtime.
• Contraindications and Side Effects:
  • Contraindications: Limited information available. Caution advised in individuals with pre-existing medical conditions. Consult a doctor before use.
  • Side Effects: Generally considered to have a low side effect profile. Some users report mild headaches or gastrointestinal discomfort.
• Potential Uses:
  • Insomnia and other sleep disorders
  • Stress reduction
  • Pain management (some preliminary research)
  • Withdrawal symptoms (limited evidence)
• References:
  • PMID: 3629414
  • PMID: 6396805
• PMID: 3629414 – [Eur Neurol. 1983;22 Suppl 1:51-8.] – Delta-sleep-inducing peptide (DSIP): general pharmacology and therapeutic possibilities. https://pubmed.ncbi.nlm.nih.gov/6396805/
• PMID: 6396805 – [Neuropeptides. 1983 Jan;3(2):115-23.] – DSIP in plasma: radioimmunological determination, sleep-promoting activity and effects on cerebral neurotransmitters and peptides. https://pubmed.ncbi.nlm.nih.gov/6396805/

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Article Summaries: #

PMID: 3629414 #

This article provides an overview of the pharmacological properties and potential therapeutic applications of Delta-sleep-inducing peptide (DSIP). The study highlights the role of DSIP in promoting sleep and its interactions with various systems in the body that may contribute to its sleep-enhancing effects.

The research results indicate that DSIP effectively promotes sleep by influencing neurotransmitter levels and improving overall sleep quality. It was also noted that DSIP has multiple effects, including potential pain relief and anxiety reduction, which may further enhance sleep.

In conclusion, the findings suggest that DSIP has promising therapeutic possibilities in the treatment of sleep disorders and possibly related conditions, such as anxiety and pain. Its unique properties make it a candidate for future studies focused on improving sleep health.

PMID: 6396805 #

This study examined the presence of DSIP in plasma and explored its sleep-promoting activity while also investigating its effects on cerebral neurotransmitters and other neuropeptides. The goal was to better understand the biochemical mechanisms by which DSIP facilitates sleep.

The results showed that DSIP levels in plasma correlated with sleep-promoting activity, supporting its role in regulating sleep. Additionally, the study found that DSIP influenced neurotransmitter levels in the brain associated with sleep and relaxation.

In conclusion, the study supports the notion that DSIP plays a significant role in encouraging sleep by balancing neurotransmitter activity in the brain. With its demonstrated effects, DSIP may offer a useful therapeutic avenue for addressing sleep-related issues in clinical settings.