BPC-157 #

• Acronym: BPC-157 (Body Protection Compound-157)
• Amino Acid Sequence: Gly-Glu-Pro-Pro-Pro-Gly-Lys-Ala-Asp-Asp-Ala-Gly-Leu-Val
• Primary Functions and Actions:
  • Promotes healing in various tissues (tendon, muscle, nervous system).
  • Protects the stomach and intestines.
  • Reduces inflammation.
• Mechanism of Action:
  • BPC-157 promotes angiogenesis (blood vessel formation).
  • Increases collagen synthesis.
  • Modulates the inflammatory response by affecting cytokines.
  • Enhances cell survival under stress.
• Systems Activated:
  • Digestive System: Protects and heals the gastric and intestinal lining.
  • Musculoskeletal System: Accelerates healing of tendons, ligaments, and bones.
  • Nervous System: May have neuroprotective effects and promote nerve regeneration.
• Dosage and Timing:
  • Dosages vary widely in studies, ranging from 1 mcg/kg to 10 mcg/kg of body weight.
  • It can be administered via subcutaneous injection.
  • Timing is not strictly defined, but many protocols suggest daily administration.
• Contraindications and Side Effects:
  • Contraindications are not well-established due to limited human studies.
  • Side effects reported are generally mild and may include pain at the injection site.
• Potential Uses:
  • Tendon and ligament healing
  • Gastric ulcers and intestinal damage
  • Inflammatory conditions
• References:
  • PMID: 24025406, PMID: 23072230, PMID: 20382354
• PMID: 24025406 – [World J Gastroenterol. 2013 Sep 28;19(36):6005-13.] – BPC 157 counteracts systemic inflammation caused by NSAIDs. https://pubmed.ncbi.nlm.nih.gov/24025406/
• PMID: 23072230 – [J Physiol Pharmacol. 2012 Sep;63(4):357-64.] – Gastric pentadecapeptide BPC 157 accelerates healing of transected rat Achilles tendon and in vitro stimulates tendocytes growth. https://pubmed.ncbi.nlm.nih.gov/23072230/
• PMID: 20382354 – [Gut. 2010 May;59(5):622-9.] – Stable gastric pentadecapeptide BPC 157 in the treatment of colitis and fistula in rats. https://pubmed.ncbi.nlm.nih.gov/20382354/

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Article Summaries: #

PMID: 24025406 #

This study explored the effects of a peptide known as BPC 157 on systemic inflammation induced by nonsteroidal anti-inflammatory drugs (NSAIDs). The researchers aimed to understand if BPC 157 could mitigate the detrimental gastrointestinal effects associated with prolonged NSAID use.

The results demonstrated that BPC 157 significantly reduced inflammation and prevented damage to the gastric and intestinal lining in animal models receiving NSAIDs. This suggests that BPC 157 could protect against the harmful effects often seen with these medications.

In conclusion, the study indicates that BPC 157 may offer a protective effect against NSAID-induced gastrointestinal complications, paving the way for potential therapeutic applications in patients requiring NSAID treatment. Its ability to counteract inflammation makes it a promising candidate for further research.

PMID: 23072230 #

This article investigated the healing properties of the gastric pentadecapeptide BPC 157 on transected Achilles tendons in rats. The research aimed to determine whether BPC 157 could speed up the recovery process in tendon injuries.

The findings revealed that BPC 157 not only accelerated the healing of the Achilles tendon in the animal models but also stimulated the growth of tendon cells (tendocytes) in laboratory settings. This suggests the peptide has regenerative properties that enhance tendon repair.

In conclusion, the study supports the idea that BPC 157 could be an effective treatment for tendon injuries, potentially leading to faster recovery. Its ability to promote cell growth and healing makes it worth considering for therapeutic use in sports medicine or injury recovery.

PMID: 20382354 #

This research focused on the effects of stable gastric pentadecapeptide BPC 157 in treating conditions such as colitis and fistula in rats. The objective was to assess its therapeutic potential in managing inflammatory bowel diseases.

The results showed that BPC 157 significantly improved symptoms of colitis and facilitated healing of intestinal fistulas. It demonstrated anti-inflammatory effects and helped restore intestinal integrity in the animal models tested.

In conclusion, BPC 157 appears to be an effective treatment for gastrointestinal disorders like colitis and fistulas, demonstrating strong anti-inflammatory properties. The positive outcomes observed in this study warrant further investigation into its use for treating similar conditions in humans, potentially expanding treatment options for patients suffering from inflammatory bowel diseases.